Papilloma virus nella trachea

When transplanted into denuded tracheal grafts, these cells can differentiate into ciliated and secretory phenotypes. We conclude that HPV E6 and E7 genes are sufficient to transform human airway epithelial cells and that the resultant cell lines express differentiated phenotypic properties that approximate those of the native epithelium.

Recurrent respiratory papillomatosis RRP is a disease in which benign noncancerous tumors called papillomas grow in the air passages leading from the nose and mouth into the lungs respiratory tract. Although the tumors can grow anywhere in the respiratory tract, they most commonly grow in the larynx voice box —a condition called laryngeal papillomatosis. The papillomas may vary in size and grow very quickly.

They often grow back after they have been removed. There are more than types of HPV, and they do not all have the same symptoms. Most people who encounter HPV never develop a related illness. However, in a small number of people exposed to the HPV 6 or 11 virus, respiratory tract papillomas and genital warts can form.

Although scientists do not fully understand why some people develop the disease and others do not, the virus is thought to be spread through sexual contact or when a mother with genital warts passes the HPV 6 or 11 virus to her baby during childbirth. RRP may occur in adults adult-onset RRP as well as in infants and small children juvenile-onset RRP who may have contracted the virus during childbirth. According to the Centers for Disease Control and Prevention CDC , estimates of the incidence for juvenile-onset RRP are imprecise but range from two or fewer cases per , children under age Even less is known about the incidence of the adult form of RRP.

Estimates of the incidence for adult-onset RPP range between two to three cases per , adults in the U. Normally, the human voice is produced when air from the lungs is pushed through two side-by-side specialized muscles—called vocal folds —with enough pressure to cause them to vibrate see illustration. Hoarseness, the most common RRP symptom, is caused when RRP papillomas interfere with the normal vibrations of the vocal folds. Eventually, RRP tumors may block the airway passage and cause difficulty breathing.

Acknowledgements We thank Maria Grazia Saladino for her help in preparation of the manuscript. References 1. Epidemiology of recurrent respiratory papillomatosis. Recurrent respiratory papillomatosis: an overview. Human papillomavirus 6, 11, and 16 in laryngeal papillomas. J Pathol. Classification of papillomaviruses PVs based on PV types and proposal of taxonomic amendments.

Malignant degeneration in laryngeal papillomatosis. Ugeskr Laeger. Human papillomavirus- associated recurrent respiratory papillomatosis is more aggressive than human papillomavirusassociated disease. Pediatr Dev Pathol. Tracheal, bronchial, and pulmonary papillomatosis in children.

An adult case of multiple squamous papillomas of the trachea associated with human papilloma virus type 6. Inter Med. Malignant transformation of recurrent respiratory papillomatosis associated with integrated human papillomavirus type 11 DNA and mutation of p J Laryngol Otol. Effectiveness of cidofovir intralesional treatment in recurrent respiratory papillomatosis.

Eur Arch Otorhinolaryngol. Dikkers FG. Treatment of recurrent respiratory papillomatosis with microsurgery in combination with intralesional cidofovir-a prospective study. Intralesional cidofovir application in recurrent laryngeal papillomatosis. Long-term results of surgical treatment for recurrent respiratory papillomatosis.

Acta Otolaryngol. Use of lasers in laryngeal surgery. J Voice. Reliability and efficacy of a new CO 2 laser hollow fiber: a prospective study of 39 patients. Radiofrequency coblation for treatment of advanced laryngotracheal recurrent respiratory papillomatosis.

Adjuvant therapy for laryngeal papillomatosis. Acta Dermatovenerol Alp Panonica Adriat. Photoangiolytic laser treatment of recurrent respiratory papillomatosis: a scaled assessment. Cundy KC. Clinical pharmacokinetics of the antiviral nucleotide analogues Cidofovir and Adefovir. Clin Pharmacokinet. Experience of 11 years use of cidofovir in recurrent respiratory papillomatosis. Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [ S 3-hydroxyphosphonylmethoxypropyl cytosine] J Med Virol.

Intermediate-term and long-termresultsaftertreatment by cidofovir and excision in juvenile laryngeal papillomatosis. Ann Otol Rhinol Laryngol. Office based treatment of laryngeal papillomatosis with percutaneous injection of cidofovir. Otolaryngol Head Neck Surg.

Intralesional cidofovir in severe juvenile respiratory papillomatosis. Current use of intralesional cidofovir for recurrent respiratory papillomatosis. Safety of intralesional cidofovir in patients with recurrent respiratory papillomatosis: an international retrospective study on RRP patients.

Squamous cell carcinoma arising in recurrent respiratory papillomatosis with pulmonary involvement: emerging common pattern of clinical features and human papillomavirus serotype association.

Mod Pathol. Lung squamous cell carcinoma arising in a patient with adult-onset recurrent respiratory papillomatosis. Jpn J ClinOncol. Presence of HPV type 6 in dysplasia and carcinoma arising from recurrent respiratory papillomatosis. Head Neck.

Role of human papillomavirus in the pathogenesis of laryngeal dysplasia. Side-effects of cidofovir in the treatment of recurrent respiratory papillomatosis. Prevalence of dysplasia in juvenile-onset recurrent respiratory papillomatosis. Arch Otolaryngol Head Neck Surg. Natural progression of dysplasia in adult recurrent respiratory papillomatosis. Degrees of dysplasia and the use of cidofovir in patients with recurrent respiratory papillomatosis. Support Center Support Center. Microscopic histologic description.

Proliferative well differentiated squamous epithelium overlying fibrovascular cores with koilocytotic change enlarged, often multiple, wrinkled nuclei May have mild to moderate dysplasia increased cellularity, loss of regularity of basal layer, hyperchromatic nuclei extending from basal to intermediate layers , mitotic activity is common Tumors in respiratory mucosa have less apparent maturation Trachea: Usually benign squamous, intermediate and ciliated cells overlying fibrovascular stroma Invasive tumor may have intracystic papillary structures, atypical invasive epithelium.

Differential diagnosis. Sign up for our Email Newsletters.